More than 120 shows, talks and films will take place during the Titanic Belfast Festival which runs from 31 March to 14 April.
Meanwhile one of the biggest global light shows ever is to be staged at the iconic, six-storey Titanic visitor centre.
Stormont minister Arlene Foster called the festival the major tourism opportunity for Northern Ireland and encouraged everyone to get involved.
“Belfast is set to host an outstanding programme of events to mark the opening of the multi-million pound Titanic Belfast attraction,” she said.
“From a breathtaking light show to commemoration services on the 100th anniversary of the ship's sinking, and a range of plays, tours, talks, films and major musical events all positioning the city as the home of the Titanic.
“I would urge everyone from across Northern Ireland not to miss out on this unique opportunity to be part of something very special.”
Lord Mayor of Belfast Niall O'Donnghaile said huge excitement is building. “There's a huge amount of events obviously centred around the opening of the Titanic signature project”.
“Events will be taking place throughout 2012 to mark the 100-year anniversary of the fateful maiden voyage of the Titanic, which sank in the north Atlantic with the loss of 1,517 lives.